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KMID : 0895820020120020011
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Journal of Oriental Rehabilitation Medicine
2002 Volume.12 No. 2 p.11 ~ p.0
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Effects of Harpagophyti Radix in Rats with Arthritis induced by Freund’s Complete Adjuvant
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Jo Yun-Hyung
Lim Hyung-Ho
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Abstract
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Objective and Methods: In order to look into the effect of Harpagophyti Radix on adjuvant arthritis, Adjuvant arthritis was infected into skin of rat’s right foot by injecting Freund’s complete adjuvant(FCA) with Rosenthale’s method. At first, rats were devided into four groups; Normal(Non-treated group with FCA), Control(Group administrated saline everyday for 2 weeks after treatment of FCA), Sample A(Group administrated Harpagophyti Radix 22.5㎎/200g everyday for 2 weeks after treatment of FCA) and Sample B(Group administrated Harpagophyti Radix 45㎎/200g everyday for 2 weeks after treatment of FCA).
Results:
1. In the right plantar edema, both of Sample groups showed a decrease in comparison with Control group.
2. In the WBC, Sample B showed a decrease with statistical significance in comparison with Control group and also Sample A showed a decrease, but did not show statistical significance.
3. In the serum total protein, total bilirubin, GOT, GPT, γ-GT and LDH, Both of Samples did not show any harmful change in comparison with Control group.
4. In the serum creatinine, BUN and uric acid, Both of Samples did not show any harmful change in comparison with Control group.
Conclusion: According to the above results, it is concluded that Harpagophyti Radix has the therapeutic effect of anti-inflammation in adjuvant arthritis with no injury to organ, and it is suggested that further studies and researchs for clinical use be needed.
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KEYWORD
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Harpagophyti Radix, Arthritis, Adjuvant
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